| Simulacrum | 7 | Illusion | | Other | Touch | V, S, M | true | Wizard | SRD5 |
| Skill Empowerment | 5 | Transmutation | | Action | Touch | V, S | | Bard, Sorcerer, Wizard, Artificer | Xanathar's Guide to Everything |
| Skybolt | 1 | Conjuration | | Action | 120ft | V, S | | Cleric, Druid, Sorcerer, Wizard | Zhenra-Khal |
| Skywrite | 2 | Transmutation | true | Other | Sight | V, S | | Bard, Druid, Wizard, Artificer | Xanathar's Guide to Everything |
| Sleep | 1 | Enchantment | | Action | 90 feet | V, S, M | | Bard, Sorcerer, Wizard, Arcane Trickster | SRD5 |
| Sleet Storm | 3 | Conjuration | | Action | 150 feet | V, S, M | | Druid, Sorcerer, Wizard | SRD5 |
| Slow | 3 | Transmutation | | Other | 120 feet | V, S, M | | Sorcerer, Wizard, Bard | SRD5 |
| Slow Healing | 1 | Evocation | | Other | Touch | V, S | | Bard, Cleric, Druid, Paladin, Ranger | Eiji-kun |
| Snare | 1 | Abjuration | | Other | Touch | V, S, M | | Druid, Ranger, Wizard, Eldritch Knight, Artificer | Xanathar's Guide to Everything |
| Snilloc's Snowball Swarm | 2 | Evocation | | Action | 90 feet | V, S, M | | Sorcerer, Wizard | XGtE, PotA |
| Soul Cage | 6 | Necromancy | | Reaction | 60 feet | V, S, M | | Warlock, Wizard | Xanathar's Guide to Everything |
| Soul Summons | 3 | Conjuration | | Action | Self | V, S | | Bard, Druid, Cleric, Sorcerer, Warlock | |
| Sound Burst | 2 | Evocation | | Action | 30ft | V, S, M | true | Bard, Cleric, Sorcerer | Zhenra-Khal |
| Sovereign's Leash | 7 | Enchantment | | Action | 80 feet | V, S, M | true | Bard, Cleric, Warlock | Venture Maidens Campaign Guide |
| Spare the Dying | Cantrip | Necromancy | | Action | Touch | V, S | | Artificer, Cleric | SRD5 |
| Speak with Animals | 1 | Divination | true | Action | Self | V, S | | Bard, Druid, Ranger | SRD5 |
| Speak with Dead | 3 | Necromancy | | Action | 10 feet | V, S, M | | Bard, Cleric, Wizard | SRD5 |
| Speak with Plants | 3 | Transmutation | | Action | Self (30-foot radius) | V, S | | Bard, Druid, Ranger | SRD5 |
| Spectral Stampede | 4 | Conjuration | | Action | Self (100-foot line) | V, S, M | | Druid, Ranger, Sorcerer, Warlock | Zhenra-Khal |
| Spider Climb | 2 | Transmutation | | Action | Touch | V, S, M | | Artificer, Sorcerer, Warlock, Wizard | SRD5 |
